The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
The Blonde Bikini Bombshell: Whatever Happened to Bo Derek?
Children of the 1970s hold dear memories of Bo Derek. With her trademark golden hair, piercing blue eyes, and braided hairstyles that banished any bad associations, she was one of the most gorgeous bombshells of her day. Since her brief moment of fame, a lot of people have been interested in learning more about her life, including where she ended up, why she stopped acting, and what her present circumstances are. Check out what Bo is doing these days.
Bo Derek’s Formative Years
Before she was known as Bo Derek, Mary Cathleen Collins was born on November 20, 1956, in Long Beach, California. Working-class parents reared Mary in a conventional American home. Her mother was a cosmetics artist, while her father was a sales executive. When Mary was a teenager, she was very interested in two things. She loved horses and was first and foremost a passionate horsewoman. She would proudly display her talents as she competed in numerous contests. She loved performing as well. She chose to enroll in acting classes in order to hone such skills.
Bo made an appearance in the 1977 film Orca. A large killer whale was seen biting off her leg in this Jaws-like movie. Her real ascent to fame, however, was primarily credited to Blake Edwards’ 1979 film “10.” Her distinctive blond braided hair began to stick out at this stage. After this one, she didn’t pursue a career in action-packed, risk-taking films. Among these were the movies “Ghosts Can’t Do It” (1990), “Bolero” (1984), and “Tarzan, The Ape Man” (1981).
partnership with John Derek
Bo first made the director John Derek, who would eventually become her husband, when she was just 16 years old. At the time, she was married to Linda Evans. It was only after a few years that they began dating. But in order to avoid the strict American regulations, they had to go to Mexico and Europe while Bo was still a child.
Soon later, John and Bo Derek tied the knot at the ages of 48 and 19, respectively. In an interview with Interview Magazine, Bo stated that she frequently felt guilty when Linda was around.I was at least partly to blame for some significant agony Linda Evans endured, according to Bo. She had been really thoughtful and courteous. Remarkably, I didn’t see her until yesterday. We were at a jewelry trunk show for charity. She was still as wonderful and delightful as ever. I always feel like sh*t when I’m with her. It’s still very much ingrained even years later.
Following that, John and Bo Derek began collaborating on projects. John would persuade her to show off her body in an effort to add some spice to his low-budget productions. This brought attention to his movies, but mostly to Bo because he was a well-known figure in Hollywood.
John Derek Was the Source of Her Braided Hairstyle Inspiration
John Derek designed the braided style for her most famous movie, “10,” although he did not direct or create it. He suggested that Bo show Blake some of his photos so that the man could judge them based on their appearance. She most certainly did. It was the late 1970s, and I asked, “How are you going to change the way you look since everything was fluffy and I’m blonde?” Bo Derek said, “I’ve always thought that would be a terrific look for me; John is a fantastic photographer.””And we tried it out. “Why don’t you show Blake these photos and see if he’ll be interested?” he said at that point. It would look great on you and be quite appropriate for the role.
Unfortunately, in 1998, John Derek passed away from a cardiovascular disease. He was seventy-one years old when he died. Bo stated that after his death, she never imagined that she would reestablish contact with anyone. The loss had devastated her.
Bo Derek, the Equestrian and Humanitarian
Bo Derek’s early passion for horseback riding seems to take precedence over her later years of fame. Even though Bo’s acting career was at its pinnacle, she made the decision to give it up. Instead, she became an activist and supporter of animal welfare. She worked very hard to protect and preserve the animals.
Bo Derek is not simply an animal lover. She also received an honorary appointment from the VA as the National Rehabilitation Special Events chair.Derek states that “VA’s National Rehabilitation Special Events promote the healing of body and spirit, which helps veterans improve their independence and live higher quality lives.” “I am deeply honored and moved to serve as the honorary chair of a truly noble cause on behalf of America’s veterans once again.”
Bo is currently married to John Corbett, the star of “Sex in the City.” They have been together for more than 20 years. They decided not to make any public announcements about their desire to marry in secret, in front of just their closest friends and family.
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