The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
20 Pics That Perfectly Explain What Having a Pet Is All About
When you have a kitty or a doggo, you’re almost sure there’s something special waiting for you at home. A pup that’s terrified when he sees you in a bath for the first time, a cat that won’t stop walking on its hind legs, and a dog that’s just crazy about… fresh carrots. They all have their own quirks, and we love them even more when we discover yet another one.
Here at Bright Side, we laughed until we cried while looking at these funny photos, and now we want you to get your daily dose of laughter too.
1. “This woman was walking around NYC with this label on her shoe.”
2. “Karen, I’m concerned, are you aware water CAN KILL YOU!?”
3. “Trained my cat to stand up. Now she won’t stop.”
4. “My name’s Mookie. I hide in mom’s purse when I’m nervous.”
5. “My dog has loose lips that get stuck on his gums after he yawns.”
6. The best way to spend time in a traffic jam
7. “So… I recently discovered my dog likes carrots.”
8. “I cannot take her seriously when she looks like this.”
9. “Me with our dog and my wife with our cat”
10. “Somebody said black cats are hard to photograph for social media. Well, meet Thor.”
11. “She thinks it’s her job to pull rocks out of the lake. The big one weighs 14 lb.”
12. When you let your white dog out after you mow the lawn:
13. “The way my cat decided to sit down”
14. “The face he makes when he knows he’s in trouble… every time!”
15. “When my cat gets spooked by a sound in the next room:”
16. “I put my inside cat outside and walked out to this 5 minutes later.”
17. Oh well… Looks like he’s comfortable…
18. “Delighted to have some uninterrupted downtime with a good book…”
19. “My cat escaped. Found her the next day outside my son’s bedroom window.”
20. “Finally got a picture of my cat looking at the camera.”
When was the last time your pet made you laugh out loud with their quirks? Do you have a funny picture of them acting out? Share your stories and pics in the comments below!
Preview photo credit KatraHigher / Twitter
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