Tragic information regarding actress Sofia Vergara validates our collective fears.
The star of Modern Family Sofia Vergara recently celebrated her 51st birthday. While her fans were thrilled for her and the fun she had with her closest friends, they couldn’t help but notice that her husband Joe Manganiello wasn’t in the pictures. Their suspicions about his absence increased when the actress wrote, “When life gives u lemons u come to Italy to squeeze them,” as a caption for one of the posts.
With a blurry picture of the couple and the remark, “¡¡¡Feliz Cumpleaños Sofía!!!”—which many branded “cold”—Jose did wish his wife a very happy birthday.
When they announced they were divorcing after almost eight years, it tragically verified the rumors that their relationship wasn’t at its finest.
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In November 2015, Sofia and Joe exchanged vows in a grandiose wedding on Palm Beach. Along with Manganiello’s True Blood co-stars Anna Paquin and Stephen Moyer, the 400 guests on their guest list included Vergara’s co-stars from Modern Family, Ariel Winter, Ed O’Neill, Eric Stonestreet, Jesse Tyler Ferguson, Julie Bowen, Sarah Hyland, and Ty Burrell. Reese Witherspoon and Channing Tatum were among the other A-list celebrities in attendance.
In 2014, when she was engaged to businessman Nick Loeb, they had their first meeting at a White House Correspondent Association dinner. After a few weeks, she ended her relationship with Nick and became involved with Joe after he requested for her number.
In reference to their encounter, Joe remarked, “I knew pretty quickly that I could trust her, and she knew pretty quickly that she could trust me,” in an interview from 2020. Furthermore, we are both the types of individuals that can put the needs of another person above our own. “I could prioritize her desires over mine, no matter what they were,” he continued. “She could do the same.” You never let go of it once you have it.
In a heartbreaking statement to PageSix on Monday, the pair revealed their intention to split, stating, “We have made the difficult decision to divorce.”
In their statement, they said, “As two people who genuinely love and care for one another, we kindly request respect of our privacy at this time as we navigate this new phase of our lives.”
“Sofía and Joe have been growing apart for a while now and are taking some distance from each other to contemplate their future,” a source close to the pair stated. “Those close to Sofia were explaining away Joe’s absence at the beginning of her big birthday trip with the excuse that he was busy filming back on the East Coast; that excuse barely held up due to the writers strike, but once the actor’s strike took effect, he could have been on the first flight,” another source continued. and it is obvious that he is not.
Therefore, nobody who is with her is even making an effort to act as though it’s still going on. It’s finished. It’s over,” they said.
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We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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